Courses are on hold due to Covid-19, but check back regularly as updates will be posted on Labyrinth’s Website.

Enable your own scientists to design with lyophilization in mind by allowing Labyrinth BioPharma to bring valuable knowledge to you. To meet the needs of your organization, we offer education in several formats: lectures, hands-on training, and webinars. Each course is customized for the needs of the audience to bring your staff up to speed quickly without wasting company resources.

Formulation and Lyophilization Consulting Services

If you have a formulation or lyophilization issues or concerns, you might consider utilizing our consulting services. Labyrinth BioPharma has the track record and ability to troubleshoot and develop formulations and lyophilization cycles to ensure product specifications are met. Consulting services include document review, site review, on-site assistance, etc.

Contact us today for more information on our consulting services.

Courses are currently on hold due to COVID-19

Free Lyophilization Webinars

Dr. Schwegman recorded a series of online webinars that could benefit scientists and lab personnel covering topics ranging from a 4-part series covering the basics theories of freeze-drying to thermal characterization. The webinars are hosted by our partner SP Scientific, the webinars are free, but you must sign-in to view the webinars.

Basic Theory of Freeze Drying – Session 1

Introduction to Freeze-Drying:

  • Basic theory

  • Brief history

  • Basic system components

  • Temperature monitoring devices

  • Vacuum monitoring devices

  • Learn tips and techniques on how to freeze dry more efficiently

Basic Theory of Freeze Drying – Session 2

Physical Properties of Materials and Thermal Characterization Techniques

  • Crystalline vs. amorphous vs. mixed systems

  • Eutectic melting, glass transition, and collapse temperatures

  • Partial collapse vs. meltback

  • Examples of failed products

  • Principals of thermal analysis

  • Thermal analysis equipment and techniques: DSC, DTA, TEA

  • Freeze-dry microscopy equipment and techniques

  • Applications of thermal analysis and freeze-dry microscopy

  • Learn tips and techniques on how to freeze dry more efficiently

Basic Theory of Freeze Drying – Session 3

Freezing, Annealing, Primary, and Secondary Drying 

  • Ice nucleation

  • Ice crystal growth

  • Effects of ice crystal particle size

  • Eutectic and or glass formation

  • The effect of freezing on ionic strength and buffer systems

  • Learn tips and techniques on how to freeze dry more efficiently

Basic Theory of Freeze Drying – Session 4

  • Scale-Up, Cycle Transfer, and Maximum Throughput Capability

  • Critical parameters in scale-up and cycle transfer

  • Scale-up strategy

  • Mapping studies

  • Dryer configuration

  • Determining and preventing choked flow conditions

  • Learn tips and techniques on how to freeze dry more efficiently

Thermal Characterization as Part of an Empirical Process for Developing Optimized Formulations and Lyophilization Cycles

Understanding the physical properties of the dried solids allows the development scientist to be able to troubleshoot, diagnose, and correct a problematic formulation and or lyophilization cycle.